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Tumor Suppressor Gene p16/INK4A Dependent Regulation of Cell Cycle Exit in a Spontaneous Canine Model of Breast Cancer Tumor Suppressor Gene p16/INK4A Dependent Regulation of Cell Cycle Exit in a Spontaneous Canine Model of Breast Cancer
Agarwal, Payal; Sandey, Maninder; DeInnocentes, Patricia; Bird, R. Curtis (2022-04-13)
16/INK4A/CDKN2A is an important tumor suppressor gene that arrests cell cycle in G1 phase inhibiting binding of CDK4/6 with cyclin D1,leaving the Rb tumor suppressor protein unphosphorylated and E2F bound and inactive. We ...