This Is Auburn

Show simple item record

Hydrogen sulfide cytoprotective signaling isendothelial nitric oxide synthase-nitricoxide dependent


Metadata FieldValueLanguage
dc.contributorYa-Xiong Tao, taoyaxi@auburn.eduen_US
dc.creatorKing, Adrienne L.
dc.creatorPolhemus, David J.
dc.creatorBhushan, Shashi
dc.creatorOtsuka, Hiroyuki
dc.creatorKondo, Kazuhisa
dc.creatorNicholson, Chad K.
dc.creatorBradley, Jessica M.
dc.creatorIslam, Kazi N.
dc.creatorCalvert, John W.
dc.creatorTao, Ya-Xiong et al
dc.date.accessioned2020-01-16T17:18:59Z
dc.date.available2020-01-16T17:18:59Z
dc.date.created2014
dc.identifier10.1073/pnas.1321871111en_US
dc.identifier.urihttps://www.pnas.org/content/pnas/111/8/3182.full.pdfen_US
dc.identifier.urihttp://hdl.handle.net/11200/49679
dc.description.abstractPrevious studies have demonstrated that hydrogen sulfide (H2S) protects against multiple cardiovascular disease states in a similar manner as nitric oxide (NO). H2S therapy also has been shown to augment NO bioavailability and signaling. The purpose of this study was to investigate the impact of H2S deficiency on endothelial NO synthase (eNOS) function, NO production, and ischemia/reperfusion (I/R) injury. We found that mice lacking the H2S-producing enzyme cystathionine γ-lyase (CSE) exhibit elevated oxidative stress, dysfunctional eNOS, diminished NO levels, and exacerbated myocardial and hepatic I/R injury. In CSE KO mice, acute H2S therapy restored eNOS function and NO bioavailability and attenuated I/R injury. In addition, we found that H2S therapy fails to protect against I/R in eNOS phosphomutant mice (S1179A). Our results suggest that H2S-mediated cytoprotective signaling in the setting of I/R injury is dependent in large part on eNOS activation and NO generation.en_US
dc.formatPDFen_US
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of Americaen_US
dc.relation.ispartofseries0027-8424en_US
dc.subjectCth; cystathionase; eNOS uncoupling; myocardial infarction; nitriteen_US
dc.titleHydrogen sulfide cytoprotective signaling isendothelial nitric oxide synthase-nitricoxide dependenten_US
dc.typeTexten_US
dc.type.genreJournal Article, Academic Journalen_US
dc.citation.volume111en_US
dc.citation.issue8en_US
dc.citation.spage3182en_US
dc.citation.epage3187en_US
dc.description.statusPublisheden_US
dc.description.peerreviewYesen_US

Files in this item

Show simple item record