This Is Auburn

Show simple item record

Genomic responses to selection for tame/aggressive behaviors in the silver fox (Vulpes vulpes)


Metadata FieldValueLanguage
dc.contributorXu Wang; xzw0070@auburn.eduen_US
dc.creatorWang, Xu
dc.creatorPipes, Lenore
dc.creatorTrut, Lyudmila N.
dc.creatorHerbeck, Yury
dc.creatorVladimirova, Anastasiya V.
dc.creatorGulevich, Rimma G.
dc.creatorKharlamova, Anastasiya V.
dc.creatorJohnson, Jennifer L.
dc.creatorAcland, Gregory M.
dc.creatorKukekova, Anna V.
dc.creatorClark, Andrew G.
dc.date.accessioned2020-07-24T19:09:47Z
dc.date.available2020-07-24T19:09:47Z
dc.date.created2018
dc.identifier10.1073/pnas.1800889115en_US
dc.identifier.urihttps://www.pnas.org/content/115/41/10398.shorten_US
dc.identifier.urihttps://aurora.auburn.edu//handle/11200/49915
dc.identifier.urihttp://dx.doi.org/10.35099/aurora-3
dc.description.abstractAnimal domestication efforts have led to a shared spectrum of striking behavioral and morphological changes. To recapitulate this process, silver foxes have been selectively bred for tame and aggressive behaviors for more than 50 generations at the Institute for Cytology and Genetics in Novosibirsk, Russia. To understand the genetic basis and molecular mechanisms underlying the phenotypic changes, we profiled gene expression levels and coding SNP allele frequencies in two brain tissue specimens from 12 aggressive foxes and 12 tame foxes. Expression analysis revealed 146 genes in the prefrontal cortex and 33 genes in the basal forebrain that were differentially expressed, with a 5% false discovery rate (FDR). These candidates include genes in key pathways known to be critical to neurologic processing, including the serotonin and glutamate receptor pathways. In addition, 295 of the 31,000 exonic SNPs show significant allele frequency differences between the tame and aggressive populations (1% FDR), including genes with a role in neural crest cell fate determination.en_US
dc.formatPDFen_US
dc.publisherNational Academy of Sciencesen_US
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of Americaen_US
dc.relation.ispartofseries0027-8424en_US
dc.rights© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.subjectbrainen_US
dc.subjectdog domesticationen_US
dc.subjectdomesticationen_US
dc.subjectevolutionen_US
dc.subjectfoxen_US
dc.subjectgene-expressionen_US
dc.subjecthistoryen_US
dc.subjectpig genomesen_US
dc.subjectrevealsen_US
dc.subjectschizophreniaen_US
dc.subjectselectionen_US
dc.subjectsequenceen_US
dc.subjectsignaturesen_US
dc.subjecttranscriptomeen_US
dc.titleGenomic responses to selection for tame/aggressive behaviors in the silver fox (Vulpes vulpes)en_US
dc.typeTexten_US
dc.type.genreJournal Article, Academic Journalen_US
dc.citation.volume115en_US
dc.citation.issue41en_US
dc.citation.spage10398en_US
dc.citation.epage10403en_US
dc.description.statusPublisheden_US
dc.description.peerreviewYesen_US

Files in this item

Show simple item record