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High activity before breeding improves reproductive performance by enhancing mitochondrial function and biogenesis


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dc.contributorWendy Hood, wrh0001@auburn.eduen_US
dc.creatorZhang, Yufeng
dc.creatorBrasher, Adam L.
dc.creatorPark, Noel R.
dc.creatorTaylor, Halie A.
dc.creatorKavazis, Andreas N.
dc.creatorHood, Wendy R.
dc.date.accessioned2022-03-13T14:34:20Z
dc.date.available2022-03-13T14:34:20Z
dc.date.created2018
dc.identifier10.1242/jeb.177469en_US
dc.identifier.urihttps://jeb.biologists.org/content/221/7/jeb177469?utm_source=TrendMD&utm_medium=cpc&utm_campaign=J_Exp_Biol_TrendMD_1en_US
dc.identifier.urihttps://aurora.auburn.edu/handle/11200/50050
dc.identifier.urihttp://dx.doi.org/10.35099/aurora-119
dc.description.abstractUnderstanding of physiological responses of organisms is typically based on data collected during an isolated event. Although many fundamental insights have been gained from these studies, evaluating the response to a single event ignores the fact that each individual has experienced a unique set of events throughout its life that may have altered its physiology. The idea that prior experiences can influence subsequent performance is known as a carry-over effect. Carry-over effects may explain much of the variation in performance found among individuals. For example, high physical activity has been shown to improve mitochondrial respiratory function and biogenesis and reduce oxidative stress, and has been linked to improved health and longevity. In this study, we asked whether the bioenergetic differences between active and inactive individuals carry over to impact performance in a subsequent reproductive event and alter a female's reproductive outcome. Female mice that had access to a running wheel for a month before mating gave birth to a larger litter and weaned a heavier litter, indicating that high physical activity had a positive carry-over effect to reproduction. Mice that ran also displayed higher mitochondrial respiration and biogenesis with no changes in endogenous antioxidant enzymes. These results provide a mechanistic framework for how the conditions that animals experience before breeding can impact reproductive outcomes.en_US
dc.formatPDFen_US
dc.publisherThe Company of Biologistsen_US
dc.relation.ispartofJournal of Experimental Biologyen_US
dc.relation.ispartofseries0022-0949en_US
dc.rightsThis is the version of record published by PUBLISHER and is made available under the CC-BY 4.0 license. Item should be cited as: Zhang, Y., Brasher, A. L., Park, N. R., Taylor, H. A., Kavazis, A. N., & Hood, W. R. (2018). High activity before breeding improves reproductive performance by enhancing mitochondrial function and biogenesis. Journal of Experimental Biology, 221(7), jeb177469.en_US
dc.subjectadaptationsen_US
dc.subjectantioxidantsen_US
dc.subjectBioenergeticsen_US
dc.subjectCarry-over effectsen_US
dc.subjectdysfunctionen_US
dc.subjectexerciseen_US
dc.subjecthistory trade-offsen_US
dc.subjectliveren_US
dc.subjectlong-distance migranten_US
dc.subjectOxidative stressen_US
dc.subjectoxidative stressen_US
dc.subjectReproductionen_US
dc.subjectRunningen_US
dc.subjectskeletal-muscleen_US
dc.subjectsuccessen_US
dc.titleHigh activity before breeding improves reproductive performance by enhancing mitochondrial function and biogenesisen_US
dc.typeTexten_US
dc.type.genreJournal Article, Academic Journalen_US
dc.citation.volume221en_US
dc.citation.issue7en_US
dc.citation.spagejeb177469en_US
dc.description.statusPublisheden_US
dc.description.peerreviewYesen_US
dc.creator.orcid0000-0002-8398-3908en_US

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