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An in vivo test of the biologically relevant roles of carotenoids as antioxidants in animals


Metadata FieldValueLanguage
dc.contributorRyan J. Weaver; RyanJWeaver1@gmail.comen_US
dc.creatorWeaver, Ryan, J.
dc.creatorWang, Phillip
dc.creatorHill, Geoffrey, E.
dc.creatorCobine, Paul A.
dc.date.accessioned2022-03-13T14:58:52Z
dc.date.available2022-03-13T14:58:52Z
dc.date.created2018
dc.identifier10.1242/jeb.183665en_US
dc.identifier.urihttps://jeb.biologists.org/content/221/15/jeb183665.shorten_US
dc.identifier.urihttps://aurora.auburn.edu/handle/11200/50052
dc.identifier.urihttp://dx.doi.org/10.35099/aurora-121
dc.description.abstractCarotenoids are well known for their contribution to the vibrant coloration of many animals and have been hypothesized to be important antioxidants. Surprisingly few examples of carotenoids acting as biologically relevant antioxidants in vivo exist, in part because experimental designs often employ carotenoid doses at levels that are rarely observed in nature. Here, we used an approach that reduces carotenoid content from wild-type levels to test for the effect of carotenoids as protectants against an oxidative challenge. We used the marine copepod Tigriopus califomicus reared on a carotenoid-free or a carotenoid-restored diet of nutritional yeast and then exposed them to a pro-oxidant. We found that carotenoid-deficient copepods not only accumulated more damage but also were more likely to die during an oxidative challenge than carotenoid-restored copepods. We suggest that carotenoid reduction, and not supplementation, better tests the proposed roles of carotenoids in other physiological functions in animals.en_US
dc.formatPDFen_US
dc.publisherThe Company of Biologistsen_US
dc.relation.ispartofJournal of Experimental Biologyen_US
dc.relation.ispartofseries0022-0949en_US
dc.rightsThis is the version of record published by The Company of Biologists and is made available under the CC-BY 4.0 license. Item should be cited as: Weaver, R. J., Wang, P., Hill, G. E., & Cobine, P. A. (2018). An in vivo test of the biologically relevant roles of carotenoids as antioxidants in animals. Journal of Experimental Biology, 221(15), jeb183665.en_US
dc.subjectastaxanthinen_US
dc.subjectAstaxanthinen_US
dc.subjectcopepoden_US
dc.subjectCopepoden_US
dc.subjectgreenfinchesen_US
dc.subjectimmune-responseen_US
dc.subjectmetabolismen_US
dc.subjectoxidative stressen_US
dc.subjectpigmentsen_US
dc.subjectprotectionen_US
dc.subjectsupplementationen_US
dc.subjectTigriopusen_US
dc.subjecttoxicityen_US
dc.titleAn in vivo test of the biologically relevant roles of carotenoids as antioxidants in animalsen_US
dc.typeTexten_US
dc.type.genreJournal Article, Academic Journalen_US
dc.citation.volume221en_US
dc.citation.issue15en_US
dc.citation.spagejeb183665en_US
dc.description.statusPublisheden_US
dc.description.peerreviewYesen_US
dc.creator.orcid0000-0002-6160-4735en_US
dc.creator.orcid0000-0001-6012-0985en_US

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