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Chemokine C-C motif ligand 33 is a key regulator of teleost fish barbel development


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dc.contributorNeil Shubin; neil.shubin@gmail.comen_US
dc.creatorZhou, Tao
dc.creatorLi, Ning
dc.creatorJin, Yulin
dc.creatorZeng, Qifan
dc.creatorPrabowo, Wendy
dc.creatorLiu, Yang
dc.creatorTian, Changxu
dc.creatorBao, Lisui
dc.creatorLiu, Shikai
dc.creatorYuan, Zihao
dc.creatorFu, Qiang
dc.creatorGao, Sen
dc.creatorGao, Dongya
dc.creatorDunham, Rex
dc.creatorShubin, Neil H.
dc.creatorLiu, Zhanjiang
dc.date.accessioned2022-10-14T16:45:11Z
dc.date.available2022-10-14T16:45:11Z
dc.date.created2018
dc.identifier10.1073/pnas.1718603115en_US
dc.identifier.urihttps://www.pnas.org/content/115/22/E5018.shorten_US
dc.identifier.urihttps://aurora.auburn.edu/handle/11200/50406
dc.identifier.urihttp://dx.doi.org/10.35099/aurora-474
dc.description.abstractBarbels are important sensory organs in teleosts, reptiles, and amphibians. The majority of similar to 4,000 catfish species, such as the channel catfish (Ictalurus punctatus), possess abundant whisker-like barbels. However, barbel-less catfish, such as the bottlenose catfish (Ageneiosus marmoratus), do exist. Barbeled catfish and barbel-less catfish are ideal natural models for determination of the genomic basis for barbel development. In this work, we generated and annotated the genome sequences of the bottlenose catfish, conducted comparative and subtractive analyses using genome and transcriptome datasets, and identified differentially expressed genes during barbel regeneration. Here, we report that chemokine C-C motif ligand 33 (ccl33), as a key regulator of barbel development and regeneration. It is present in barbeled fish but absent in barbel-less fish. The ccl33 genes are differentially expressed during barbel regeneration in a timing concordant with the timing of barbel regeneration. Knockout of ccl33 genes in the zebrafish (Danio rerio) resulted in various phenotypes, including complete loss of barbels, reduced barbel sizes, and curly barbels, suggesting that ccl33 is a key regulator of barbel development. Expression analysis indicated that paralogs of the ccl33 gene have both shared and specific expression patterns, most notably expressed highly in various parts of the head, such as the eye, brain, and mouth areas, supporting its role for barbel development.en_US
dc.formatPDFen_US
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of Americaen_US
dc.relation.ispartofseries0027-8424en_US
dc.rights© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.subjectbarbelen_US
dc.subjectcatfishen_US
dc.subjectchannel catfishen_US
dc.subjectchemokineen_US
dc.subjectcxcr4en_US
dc.subjectdiseaseen_US
dc.subjectgeneen_US
dc.subjectgerm-cell migrationen_US
dc.subjecthypoxia responsesen_US
dc.subjectregenerationen_US
dc.subjectrna-seqen_US
dc.subjectsiluriformesen_US
dc.subjectzebrafishen_US
dc.titleChemokine C-C motif ligand 33 is a key regulator of teleost fish barbel developmenten_US
dc.typeCollectionen_US
dc.type.genreJournal Article, Academic Journalen_US
dc.citation.volume115en_US
dc.citation.issue22en_US
dc.citation.spageE5018en_US
dc.citation.epageE5027en_US
dc.description.statusPublisheden_US
dc.description.peerreviewYesen_US

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